Multiplexed measurement of miRNA in tissue sections
A key component of medical studies
Spatially resolved gene expression patterns are emerging as a key component of medical studies, including companion diagnostics, yet technologies for quantification and multiplexing are limited. This project is developing a method to perform spatially-resolved and multiplex microRNA measurements directly from formalin-fixed, paraffin-embedded tissue. This technology could be used to quantify the heterogeneities in tissue samples and lead to informed biomarker-based diagnostics.
Spatially Resolved and Multiplexed MicroRNA Quantification from Tissue Using Nanoliter Well Arrays
Published in Nature’s Microsystems & Nanoengineering journal