Exploring the therapeutic potential of small molecules that modulate the c-Myc oncoprotein

Year 2015
Project team Angela Koehler with Francisco Caballero and Eric Stefan

A therapeutic stress strategy in oncology

Controlling the function of overactive transcription factors is an emerging therapeutic stress strategy in oncology. The team has identified compounds that bind to protein complexes containing the prolific oncoprotein c-Myc and found a subset that modulate Myc-driven functions in cells, including Myc-mediated transcription. They will explore the therapeutic potential of Myc modulation.

Kronos Bio

The technology from this project was spun out into a startup company, Kronos Bio.

Angela Koehler presents their project at IdeaStream 2016.