Combinatorial engineering of Chimeric Antigen Receptors

Year 2019
Project team Michael Birnbaum with Taeyoon Kyung, Michael Hemann, and Khloe Gordon

Extending therapeutic efficacy

Chimeric Antigen Receptor (CAR) T cell therapies have shown success treating blood cancers such as lymphomas and leukemias. However, they have not been successfully used with solid tumors. This project used a unique approach to create hundreds of thousands of CARs and to select for those that show superior activity under physiologically relevant conditions. The hope is to identify CARs capable of extending therapeutic efficacy to other disease implications.

Taeyoon Kyung presented Novel Platform for Engineering CAR-T cells for Cancer Immunotherapy at IdeaStream 2020.