Combinatorial engineering of Chimeric Antigen Receptors
Extending therapeutic efficacy
Chimeric Antigen Receptor (CAR) T cell therapies have shown success treating blood cancers such as lymphomas and leukemias. However, they have not been successfully used with solid tumors. This project used a unique approach to create hundreds of thousands of CARs and to select for those that show superior activity under physiologically relevant conditions. The hope is to identify CARs capable of extending therapeutic efficacy to other disease implications.