Controlling the function of overactive transcription factors is an emerging therapeutic stress strategy in oncology. The team has identified compounds that bind to protein complexes containing the prolific oncoprotein c-Myc and found a subset that modulate Myc-driven functions in cells, including Myc-mediated transcription. They will explore the therapeutic potential of Myc modulation.
The technology from this project was spun out into a startup company, Kronos Bio.
Watch Angela present their project at IdeaStream 2016 below.