Combinatorial engineering of Chimeric Antigen Receptors

Michael Birnbaum with Taeyoon Kyung, Michael Hemann & Khloe Gordon

Chimeric antigen receptor (CAR) T cell therapies have shown success treating blood cancers such as lymphomas and leukemias, however they have not been successfully used with  solid tumors. This project will use a unique approach to  create hundreds of thousands of CARs and to select for those that show superior activity under physiologically relevant conditions. The hope is to identify CARs capable of extending therapeutic efficacy to other disease implications.

See Taeyoon Kyung present their project at IdeaStream 2020 below.