Rapid diagnosis of bacterial infection via volatile...2019 | Max Shulaker with Eric Rosenberg
Early diagnosis of the specific type of bacterial infection is critical in improving clinical outcomes: early initiation of appropriate antibiotic... Read more
Rapid, target-directed antimalarial drug discovery2019 | Jacquin C. Niles with Mai Nakashima, Khan T. Osman &, et al.
Malaria remains a major global human health problem. With no efficacious vaccine available, the disease is treated using antimalarial drugs to which... Read more
Combinatorial engineering of Chimeric Antigen...2019 | Michael Birnbaum with Taeyoon Kyung, Michael Hemann &, et al.
Chimeric antigen receptor (CAR) T cell therapies have shown success treating blood cancers such as lymphomas and leukemias, however they have not... Read more
Polymer-drug conjugate for osteoarthritis2019 | Paula Hammond & Alan Grodzinsky with Brandon Johnston
Osteoarthritis affects 30 million Americans, however, there exists no drug that can slow disease progression. This project is developing a... Read more
Acoustic fluid level detection for wells2019 | Choon Tan with Sebastien Mannai
Over-pumping is a key cause of oil well failures in the USA. Over-pumping also generates millions of tons of CO2 due to vented and flared natural gas... Read more
Robust anti-fouling ultrafiltration membranes2018 | Jeffrey Grossman with Brendan Smith
Food and beverage, oil and gas, industrial waste treatment and biopharmaceutical industries separate chemicals either through distillation or using... Read more
In-line photonic Raman sensors for accelerated...2018 | Juejun Hu with Derek Kita & Jérôme Michon
The rising cost of bringing a new drug to market has increased the pressure to accelerate the pharmaceutical development cycle. Understanding and... Read more
Turbocharging single-cylinder engines to increase...2018 | Amos Winter and Michael Buchman
Many diesel-powered devices (delivery vehicles, tractors, generators, etc.) in emerging markets use single-cylinder engines. They have to meet ever... Read more
Hydrogel for reducing immune-related adverse events...2018 | Jeremiah Johnson with Sachin Bhagchandani & Farrukh, et al.
Cancer treatments, especially new immunotherapies, but also traditional chemotherapy, have adverse immune side effects. To reduce the side effects of... Read more
A novel prodrug platform as the next generation...2018 | Jeremiah Johnson with Yivan Jiang, Hung Nguyen &, et al.
Multiple Myeloma (MM) is a deadly blood cancer that has 30,000 new diagnoses each year. In 2022, the market for treating this cancer is expected to... Read more
Biomass torrefaction for high-yield,...2018 | Ahmed Ghoniem with Sonal Thengane & Kevin Kung
Many smallholder farmers in rural areas depend on costly, imported synthetic fertilizers that over the long term may acidify and degrade their soils... Read more
Producing E. coli test kits in Nepal2018 | Jeffrey Ravel & Susan Murcott
E. coli is a bacterium indicating fecal contamination in water that causes life-threatening diarrhea and dehydration in millions worldwide. In 2008,... Read more
Optically transparent thermally insulating...2017 | Evelyn Wang, Gang Chen & Xuanhe Zhao with Elise, et al.
Every year, windows in the United States lose enough energy to power over 85 million homes. This wasted energy costs $20 billion and generates more... Read more
Engineered binding proteins as replacements for...2017 | Hadley Sikes with Eric Miller & Ki Joo Sung
Protein biomarkers can be used to indicate illness and injury in humans and in organisms that are consumed as food. Assay development is limited by... Read more
Low-cost spectroscopy solutions for Raman sensing...2017 | Rajeev Ram with Amir Atabaki
The cost and size of high-performance spectroscopy instruments often limits their application. This project leverages recent advances in photonic... Read more
Engineered protein treatments for hair repair and...2017 | Bradley Olsen with Hursh Sureka, Justin Paloni & Sieun, et al.
Repeated washing, drying, straightening, and dyeing of hair breaks the protective cuticle and damages the hair. Treatment with lipids protects the... Read more
Digital 3D Printing of Microparticles2017 | John Hart with Justin Beroz and Ulrich Muecke
On-demand production, especially for complex and high value parts, would be valuable to many industries. Additive manufacturing processes broadly aim... Read more
Development of synthetic substrates for...2017 | Paula Hammond & Linda Griffith with Marianna Sofman
As the prevalence of neurodegenerative diseases continues to grow, there has been increased attention toward advancing stem cell therapies. This... Read more
Local Drug Delivery for Facilitating Expedited...2017 | Michael Cima with Christopher Lee and Brian Eisner
Twelve percent of men and five percent of women will experience at least one symptomatic urinary stone by age 70. Stones when lodged in the ureter... Read more
Structured Nucleic Acid Nanoparticle Therapeutic...2017 | Mark Bathe, Darrell Irvine, Feng Zhang with Remi, et al.
Targeted, efficient delivery of nucleic acid therapeutics is one of the largest current bottlenecks to the treatment of human diseases. This project... Read more