Active Projects

System for on-site detection of virus-loaded aerosol

2021 | Domitilla Del Vecchio, Hsin-Ho Huang, Carlos Barajas, et al.

With major medical epidemics happening every 2-6 years, the spread of infectious disease poses a continuous risk. The global medical community... Read more

Chronic brain implant to deliver antiepileptic...

2021 | Michael J. Cima, Max Cotler, and Hannah Jackson

The team will perform preclinical rodent studies to directly deliver antiepileptic medication to seizure regions in the brain. With direct drug... Read more

AI support system for authoring clinical...

2021 | David Karger, David Sontag, Steven Horng, Monica, et al.

This team is developing MedKnowts, a system combining machine learning and human-computer interaction to reduce the effort needed both to synthesize... Read more

System to improve protein production in cells

2021 | Peter Dedon and Shane Byrne

Based on their discovery of a system that regulates protein synthesis in cells, this team is developing a platform to improve protein production in... Read more

Continuous directed evolution in mammalian cells

2021 | Matthew Shoulders, Sam Hendel, Amit Choudhary, and, et al.

This project strives to enable the rapid and continuous directed evolution of high-value protein targets, such as genome editors and molecular... Read more

Robotic guidewire to treat neurovascular disease

2021 | Xuanhe Zhao and Yoonho Kim

Neurovascular diseases, including stroke and aneurysms, are medical conditions with significant morbidity and mortality rates worldwide. Early... Read more

Color-changing photonic sheets

2021 | Mathias Kolle with Ben Miller

A material that changes color to provide visual feedback about movement and pressure offers unique possibilities for medical and other products. The... Read more

Local hydrogel-mediated delivery of interventions...

2020 | Natalie Artzi with Henry Brem and Michelle Zarrella, et al.

This team focused on glioblastoma is developing injectable, adhesive hydrogels to mediate controlled local delivery of therapies. Read more

Solid-state drones

2020 | Steven Barrett & David Perreault

After demonstrating near-silent drone propulsion for brief flights, this project will focus on a small drone that flies for 10 to 30 minutes. Read more

Single-cell encapsulation methods for enhancing...

2020 | Ariel Furst with Chelsea Catania

This team is developing a self-assembling coating for the protection of microorganisms in the probiotics manufacturing process. Read more

Real-time speech modification system to enhance...

2020 | Satrajit Ghosh & Tod Machover with Rebecca Kleinberger

This team has developed a portable solution to reduce stuttering using novel alterations of auditory feedback during speech production. Read more

Noninvasive assessment of pulmonary edema using...

2020 | Polina Golland with Ruizhi Liao, Steven Horng, and Seth, et al.

This team uses machine learning algorithms to automatically assess the severity of pulmonary edema from chest X-ray images, providing a more complete... Read more

Automated human oocyte cryopreservation device

2020 | Linda Griffith & Scott Manalis with Max Stockslager

The project aims to design a fully automated oocyte vitrification system, capable of successfully repeating the vitrification process in a reliable... Read more

Ultrawide field-of-view metasurface flat-optics...

2020 | Juejun Hu & Tian Gu with Mikhail Shalaginov

This project is developing novel metasurface flat optics for ultra-compact, high-performance optical imaging, sensing, projection, and display.  Read more

Cleavable additives for degradable, recyclable...

2020 | Jeremiah Johnson with Peyton Shieh and Keith Husted

This team is developing recyclable versions of existing high-performance thermosets by incorporating small quantities of a degradable co-monomer. Read more

Augmentative communication technologies using...

2020 | Pattie Maes & Rosalind Picard with Jaya Narain, et al.

This project is developing a full-feedback augmentative-communication system, using a database of vocalizations from individuals and machine learning... Read more

Novel device for obstructive sleep apnea in Down...

2020 | Ellen Roche, Ravi Rasalingam & Tarsha Ward with David, et al.

This team has created a custom-fit oral prosthesis that stabilizes the mouth muscles and prevents obstruction of the airway at night. Read more

A prototype of low-cost aluminum molten salt...

2020 | Donald Sadoway with Ji Zhao and Sherrie Qian

This team aims to demonstrate a prototype of a radically new battery based on aluminum metal and common molten salt. Read more

Wide-field-of-view chip-scale LiDAR for autonomous...

2020 | Marin Soljačić with Josué López and Thomas Mahony

 This team is developing a next-generation LiDAR sensor that will enable autonomous machines and vehicles to see and navigate. Read more

Point-of-care integrated sample-sparing system for...

2020 | Joel Voldman with Bruce Levy, Rebecca Baron, and, et al.

This sepsis project aims to create a portable automated prototype system suitable for obtaining large-scale data from human disease samples. Read more