Novel Approaches to Antibody-Drug Conjugates

Stephen Buchwald and Bradley Pentelute with Timothy Senter and Chi Zhang

Antibody-Drug Conjugates (ADCs) for cancer therapy are synthesized by attaching cytotoxic small molecule drugs to monoclonal antibodies, using chemical linkers. The team is developing novel linkers to attach drugs to antibodies. These linkers should allow for a much more effective cancer therapy.

Watch Tim present their project at IdeaStream 2016 below.