Multiplexed measurement of miRNA in tissue sections

Patrick Doyle & Frank Slack with Maxwell Nagarajan

Spatially-resolved gene expression patterns are emerging as a key component of medical studies, including companion diagnostics, yet technologies for quantification and multiplexing are limited. This project is developing a method to perform spatially-resolved and multiplex microRNA measurements directly from formalin-fixed, paraffin-embedded tissue. This technology could be used to quantify the heterogeneities in tissue samples and lead to informed biomarker-based diagnostics.
See Maxwell Nagarajan present their project at IdeaStream 2020 below.