Efficient Drug Discovery Screening

Paul Blainey with Anthony Kulesa, Jared Kehe and Prianca Tawde

In the United States, antibiotic-resistant infections cause >23,000 deaths and $20-35 billion in direct healthcare costs. Modern biology suggests that combinations of drugs are more effective than a single antibiotic, however, screening all combinations is an intractable challenge. This project plans to bring combinatorial discovery within reach by lowering costs and increasing throughput >6-fold over the current state-of-the-art.